department of neurology  
Columbia University Medical Center | Department of Neurology
» close window
Serge Przedborski, MD, PhD
Page and William Black Professor of Neurology, Pathology and Cell Biology
Vice-Chair of Research, Department of Neurology
Co-Director, Center for Motor Neuron Biology and Disease
Director, Columbia Translational Neuroscience Initiative
Columbia University Medical Center, New York, NY


  • MD: University of Brussels, Brussels, Belgium
  • PhD: University of Brussels, Brussels, Belgium
  • Residency: Erasme University Hospital, Brussels, Belgium
  • Fellowship: Neurological Institute, Columbia University, New York, NY
Board Certification:
Belgian Board of Neurology and Psychiatry

» Przedborski Neuroscience Research Lab
» Center for Motor Neuron Biology and Disease
» Columbia Translational Neuroscience Initiative
» Division of Movement Disorders

» Recent Publications

Dr. Przedborski's academic interests focus on the molecular and cellular biology of neurodegenerative disorders such as Parkinson's disease (PD) and Amyotrophic Lateral Sclerosis (ALS). His ongoing research aims at understanding the contributions of cell-autonomous and non cell-autonomous mechanisms to neurodegeneration using both toxic and genetic experimental models of PD and ALS. In keeping with this goal, how alterations in mitochondrial biology, especially of mitochondrial dynamics and mitophagy, provoke degeneration of specific subpopulations of neurons is one of the main areas of research in the Przedborski laboratory. To what extent and by which mechanisms do non-neuronal cells, like microglia and astrocytes, participate in the demise of neurons in neurodegenerative disorders, such as PD and ALS, represent a second main line of research in this laboratory. A list of relevant publications can be found at: These research efforts are supported by federal grants from both NIH and the DoD as well as by several private agencies such as the Parkinson's Disease Foundation and the Thomas Hartman Foundation. Dr. Przedborski is a Senior Editor for the Journal of Neuroscience and an Associate Editor of Movement Disorders. He also serves as an ad hoc Reviewer for the National Institutes of Health, the Veterans Adminsration, the Department of Defense, the Canadian Medical Research Council, and various medical journals including Science, Nature, Nature Neuroscience, Neuron, the New England Journal of Medicine, and the Proceedings of the National Academy of Science USA.

Doctors, Department of Neurology
© 2012 The Neurological Institute of New York • 710 W 168th St, New York, NY 10032
Department of Neurology | Columbia University Medical Center | Last updated: December 4, 2012 | Comments
Neurology Columbia University Medical Center